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Stepping out of the lab creates new challenges for technology ventures. Scale, equipment, operations and logistics related questions are becoming the focal point of works. Technological flexibility decreases while associated costs and potential risks are simultaneously increasing. A technology freeze and a process concept become necessary - without suppressing but balancing fruitful new ideas that are continuously arising. Flaws within downstream processing or commercialization strategies can now easily become problematic once entering the existing piloting & biomanufacturing landscape.